This research is identifying about how humor or comedy can be used as a way to deliver a message. Stand-up Comedy as a single comedy style has become one of the most popular show in Indonesia nowadays. Stand-up Comedy is considered as a new way to deliver a message that is actually heavy even taboo to be discussed in the face of the public. However, social issues can be main topic in stand-up comedy material, including East Indonesia issues. This research focusses on the social issues of East Indonesia, where obstacles in various aspects of development is still happening in this particular region. Not many of the Stand-up comedian that is usually known as comics that consistently brought East Indonesian social issues, and this is the reason that leads this research to take place. As region in east Indonesia, those are social issues that rarely discussed in young forum in Indonesia, especially in young group communities. With Consequentiality of Communication theory and Coordinated Management of Meaning theory this research try to analyze how process of the message created then become act on a stage. The result of this research showed that material preparation and stage act become the important factors in support communication process in comedy act. Furthermore, the messages will be easy to deliver if there is proximity between the comic and materials. The resume of this research shown that stand-up comedy was not just about jokes, but a way to deliver particular messages even hard issues to the audience by not patronizing.