Digital innovation has emerged as a key success factor for an organization facing recent digital challenges, including human resources management. Either private or public organizations urge to tackle those challenges in maintaining employee performance and satisfaction. This study aims to examine the relationship between workloads, digital innovation, and employee job satisfaction in Social Security Administrator for Health (BPJS Kesehatan), Indonesia. Data were obtained from 384 samples of proportionated job levels of BPJS Kesehatan’s employees through online questionnaires. Data analysis used Partial least squares structural equation modeling (PLS-SEM). Findings from this study show that (1) workloads have a negative and significant effect on digital innovation, (2) digital innovation has a positive and significant effect on job satisfaction, (3) Meanwhile, workloads have no significant effect on job satisfaction, (4) Remarkably, digital innovation acts as an intervening variable of workloads to job satisfaction (full-mediation). This study provides new insight into that digital innovation can be a fully mediating variable on the effect of workloads on job satisfaction. Separately, job satisfaction is not induced directly by workloads.